In the future, joint work with other disciplines such as toxicology will be needed to further clarify the connection. Alexandra Schneider, head of the working group at the EPI and first author of the study. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy. The antigen receptors are small and are repelled by the large adhesion molecules. If an immune cell recognises foreign matter, it can present it to another immune cell.
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Press Release – Helmholtz Zentrum München
Microscope image shows an immunological synapse. They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse. Statistical cookies Matomo Permit cookies that help us to analyse the page views and user behavior on our websites.
This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them. Alexandra Schneider, head of the working group at the EPI and first author of the study.
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The ring pattern is thus a result of mechanical forces in the cell membrane which sorts the molecules in the synapse according to their size. To do this, T-cells make contact with the antigen-presenting immune cells and read information from their surface. In recent years, figures have shown a certain dynamics: The results for Brandenburg revealed a percent increase in the burden of disease. The focus is on the development and progression of metabolic, respiratory and allergic diseases, as well as heart diseases and mental health.
Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
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To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. Existing levels of air pollution on busy roads and at traffic hot spots were not included in the study. T-cells red and B-cells blue form immunological synapses at their contact point green. Further studies on the effects of air pollution on diabetes, allergies, respiratory and cardiovascular diseases as well as on mental health will be conducted in interdisciplinary teams.